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The Hormonal Connection: How Mounjaro Might Influence Menstrual Cycles Mounjaro works by mimicking two naturally occurring gut hormones - GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

"About 15 years ago, there was a tremendous boom in weight loss surgery, gastric bypass, those sorts of things but what you're seeing now with GLP-1s far exceeds what we ever saw with natural weight loss or with surgical weight loss." But, Matarasso notes, it's not the GLP-1s themselves that are causing the issue it's the rapid weight loss they can trigger, which may lead to loose skin