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The most frequent adverse events reported were nausea, constipation, fatigue, decreased appetite, injection site erythema, and injection site reaction, followed by vomiting, headache, diarrhea, dyspepsia, and nasopharyngitis (Table 3)

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Using computer-assisted image analysis (25) of sections stained for the endothelial junction molecule CD31 (29), we found pronounced vascular remodeling during the synchronized hair cycle in adult mice, with a more than fourfold increase in the average vessel size from early anagen (day 1) to late anagen (day 12)