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1e therefore also seems unlikely

GLP-1 analogues, such as semaglutide, are prescribed for people with type 2 diabetes, including those with the condition who have obesity, in order to promote weight loss and improve control of blood sugars

Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

Standard doses work for many, but some need adjustments