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In a phase II trial, obese participants who were administered retatrutide lost an average of 24.2 percent of their body weight over a 48-week period, Wired noted, which is more than what other drugs have achieved in nearly twice the amount of time
Landmark trials, including CREDENCE, DAPA-CKD, EMPA-KIDNEY, and FLOW, have demonstrated their efficacy in preserving kidney function and reducing adverse outcomes
[17] [18] As a precaution, individuals with a personal or family history of medullary thyroid carcinoma or MEN2 are typically excluded from trials
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