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This extra mechanism provides the following benefits: Greater appetite suppression and glucose control due to additive effects when combined with GLP-1 agonism Improving how fat cells respond to insulin , which provides more effective blood sugar control Promoting the breakdown of fat cells resulting in more effective weight loss How effective are GLP-1 medications

GLP-1 medications are approved for adults who have a body mass index (BMI) of 30 or higher, or a BMI of at least 27 plus a weight-related medical condition, such as the following: Type 2 diabetes High blood pressure High cholesterol Obstructive sleep apnea Cardiovascular disease that increases the risk of heart attack or stroke MASH, or metabolic dysfunctionassociated steatohepatitis, a form of liver inflammation Avlin Imaeda, MD, PhD, a Yale Medicine gastroenterologist who is board-certified in obesity medicine, notes that qualifying for the medication based on heart disease aloneoften necessary for insurance coveragecan be challenging

Pfizer (NYSE:PFE) reported Phase 2b results for its GLP-1 anti-obesity candidate, PF-08653944, showing potential for a once monthly injection

Mojsov and Nathan continued to rewrite and resubmit their paper after Mojsov returned to New York