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doi: 10.1111/bcp.15499 20 HuangJZhaoYCaoYZhangQRanDLiJet al

We need to move our thinking to getting people on these guideline-directed therapies that improve substantial outcomes like death at an early stage. Pantalone said first-line therapy may become individualized for each patient, with SGLT2 inhibitors being used for some people with CKD and semaglutide being prescribed to others

The Phosphodiesterase (PDE) 4 inhibitor roflumilast, which is clinically approved for chronic obstructive pulmonary disease (COPD), has been reported to reverse BLM-induced elevations in glycine and proline and moderately restore levels of glutamate, alanine, and arginine