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Because of climate change, global and local environmental systems are changing and breaking down and becoming more unpredictable

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they play key roles in the regulation of three physiological processes: Blood coagulation: prothrombin (factor II), factors VII, IX, and X, and proteins C, S, and Z [50] Bone metabolism: osteocalcin, matrix Gla protein (MGP), [51] periostin, [52] and Gla-rich protein