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Funding This study was supported by the Brussels Region Innoviris (Bridge) project DiaType, the Eye Hope Foundation, the Alianza de familias afectadas por el syndrome de Wolfram (AFASW), the Fonds National de la Recherche Scientifique (FNRS), the Fonds Erasme for Medical Research, the Walloon Region SPW-EER Win2Wal project BetaSource, the Francophone Foundation for Diabetes Research (FFRD, which is sponsored by the French Diabetes Federation, Abbott, Eli Lilly, Merck Sharp & Dohme and Novo Nordisk) and the Pandarome project (40007487), which has received funding from the FWO and FRS-FNRS under the Excellence of Science (EOS) programme