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Histopathological studies of the liver of HFD-fed rats revealed steatosis, which was alleviated by LC administration, while atorvastatin had no effect on the treatment of hepatic lesions

Ligand binding triggers receptor autophosphorylation and recruitment of insulin receptor substrate (IRS-1, IRS-2) and Shc adapter proteins, activating the PI3KAktmTOR and RasRafMEKERK signaling cascades