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Patients often experience reduced hunger and significant weight loss

Studies have shown that reduced sleep is associated with a decreased GLP-1 level in the blood, especially in the afternoon, and poor fullness scores, says Vergara

GLP-1 receptor agonists have shown consistent benefit in PCOS: a 2022 meta-analysis in Human Reproduction Update (N=10 trials, 484 women) found that GLP-1 agonist therapy reduced fasting insulin by 1.98 mIU/L, total testosterone by 0.19 nmol/L, and improved menstrual regularity in 55% of participants [10]