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Notably, when allopurinol doses are less than 300 mg daily, less than half of patients achieve the therapeutic target of a serum uric acid (SU) concentration less than 6.0 mg/dL

Clinicians should also monitor nutritional risks associated with rapid weight loss, such as deficiencies in iron, folic acid, and B vitamins, to ensure the patient is pregnancy-ready rather than just weight-ready. Given that GLP-1RAs improving IVF outcomes remains limited, their appropriate positioning remains a metabolic optimization tool before ART rather than a standardized pretreatment regimen ( 7 From evidence to decision: estimating net benefit under uncertainty Clinical decisions around GLP-1RAs in fertility-focused PCOS care are rarely binary

But with new tablets launching in the U.S