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These findings demonstrate a previously unrecognized capacity of YPEL5 to recruit CTLH substrates and enable the discovery of MGDs for exceedingly common acidic and basic degrons

However, the human bodys ability to absorb oral B12 is limited due to glycoprotein in the digestive tract which limits the bioavailability of B12

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We observed that predicting aqueous solubility was consistently superior to predicting intrinsic solubilityaqueous-solubility-prediction models generally had an of 0.750.80 while intrinsic-solubility-prediction models had an of 0.550.65 (Figure 2)