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This reduction makes mitochondria more susceptible to damage from free radicals, leading to mitochondrial DNA depletion and dysfunction (Salete-Granado et al., 2023)

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HCC / Risk Adjustment (v28) Under the CMS-HCC Model v28 (effective for payment year 2026), Crohns disease and associated conditions map to the following Hierarchical Condition Categories: For Medicare Advantage patients with Crohns disease, annual risk adjustment requires recapture of HCC 35 (IBD) each calendar year

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