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It is well-established that adverse reaction analyses based on the FAERS database have the following limitations: passive reporting systems, heterogeneous data quality, difficulty in eliminating confounding factors, and an inability to establish causality [Reference Zou, Li, Wang, Deng, Wang and Hua51, Reference Zhao, Long and Wang52]

Cabe sealar que la paciente del caso 4 se neg a someterse a un tratamiento antibacteriano y aunque los efectos remitieron espontneamente la paciente presentaba como secuela escaras depresivas e hiperpigmentadas en los lugares donde se localizaban las ppulas (6)