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The data generated during this phase help define the dose range that may be explored in subsequent studies and contribute to understanding exposure-response relationships, pharmacokinetic behavior and safety considerations associated with the investigational compound

Nanoparticles containing bFGF (5 L) were pipette-administered to alternate nostrils of deeply sedated rats in this investigation

1991, 54: 113S-118S

No published study has linked BPC-157 to tumorigenesis, and Sikiric's group has explicitly noted the absence of neoplastic findings in chronic dosing models 1