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Description

The amido group is used to activate the ribose backbone, using PRPP amidotransferase, the first committed step of de novo purine synthesis, as well as to produce carbamoyl phosphate in the first step of pyrimidine metabolism

6, Cas12f packaged into endosome-derived EVs via CD63 exhibited higher protein loading per EV but significantly lower genome-editing efficiency than Cas12f packaged into MIM-induced EVs