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One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176
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In addition, the article reviews the clinical progress of GLP-1R agonists, including their efficacy, safety and potential in the treatment of diabetes and related complications
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