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55 The discovery of KIT and BRAF mutations and the development of novel immunotherapeutic agents that specifically target and inhibit these oncogenic pathways have provided new alternative treatments

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The landmark work here showed that short-chain fatty acids stimulate GLP-1 release through FFAR2, in cell systems and in mice ( Tolhurst et al., 2012 )

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Tirzepatide is a dual agonist, meaning it can bind to either receptor type

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