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Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre open-label randomised phase 3a trial

Last reviewed: July 20, 2026 Last updated: July 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Tirzepatide, a dual GIP and GLP-1 receptor agonist, showed even greater weight reduction in clinical trials, with some participants losing 20% or more of body weight