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Intriguingly, Godex-treated mice did not show differences in lipid oxidation and energy expenditure compared with HFD mice and no significant change was observed in browning markers such as UCP1 and CD137 in adipose tissue despite changes in body weight and visceral fat volume

The signal is unmistakable: innovation is no longer solely about which molecule works best, but how reliably and scalably it can be delivered to patients

Lam et al., 2022)