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TNF- activates nicotinamide adenine dinucleotide phosphate oxidase (NOX), producing ROS [2], creating a vicious cycle

Central visceral hypersensitivity/pain may also involve the persistent activation of dorsal horn neurons, resulting in changes within the spinal cord that can mediate pain long after resolution of inflammation or other pelvic insult

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Processed foods, excessive sugar, and refined carbohydrates can promote inflammation and insulin spikes that counteract the peptides benefits