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doi: 10.1371/journal.pone.0288718 Summary Keywords GLP-1 receptor agonists, gut microbiome modulation, incretinmicrobiota axis, metabolism, therapeutic response variability Citation De La Motte LR, Carreras F and Drago L (2026) The gut microbiota as a potential determinant of response to GLP-1 receptor agonists: a narrative review

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Understanding how these medications interact with your metabolismand how to preserve metabolic health through resistance training, adequate protein intake, and regular monitoringis essential for achieving optimal outcomes whilst minimising unwanted effects on lean tissue and energy expenditure

Very few go beyond that for peptides reconstituted with bacteriostatic water