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As of July 26, 2026, 21 CFR 216.23 lists six substances that can be used through this pathway: Brilliant Blue G, cantharidin for topical use only, diphenylcyclopropenone for topical use only, N-acetyl-D-glucosamine for topical use only, squaric acid dibutyl ester for topical use only, and thymol iodide for topical use only
If you're experiencing intense purging, reducing frequency can ease the transition while still allowing the product to work
Takizawa T, Huang IY, Ikuta T, Yoshida A
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