Among these, the autotransporters App and MspA can reach the nucleus, where they bind and cleave Histone H3 through their serine endopeptidase activity
Some researchers credit GLP-1s ability to reduce inflammation, which promotes cancer cell growth and spread
We searched PubMed, Web of Science, and Embase from inception through April 2025 using the terms GLP-1 receptor agonists, GLP-1RAs, neurodegeneration, Alzheimer's, Parkinson's, multiple sclerosis, ALS, mechanisms, clinical trials, and biomarkers. Studies were included if they were English-language, peer-reviewed, and focused on central nervous system effects
Chronic stress elevates cortisol, which promotes visceral fat storage and undermines weight loss