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This is explained by their ability to reduce excessive neuronal excitability through hyperpolarization of pyramidal neurons in the prefrontal cortex (5)

Gut microbiome and its role in obesity and insulin resistance

This study found that the majority of patients stop these drugs within a year, which could be related to how much weight loss they experience, whether they have side effects and how relatively affordable the medications are

Insulin is one, as is the active ingredient of GLP-1 obesity drugs