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Role of NAD + in oxidative stress Oxidative stress arises from an imbalance between excessive production of ROS and the capacity of antioxidant defense systems

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Healthy aging is defined as the accumulation of time dependent cellular damage which factors include oxidative stress, epigenetic changes, genomic instability, telomere attrition, and dysregulation of cell signaling and inflammatory responses, upon further hit, this natural disruption may become detrimental [53]

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