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Consequently, PGA formation constitutes an overflow pathway that becomes prominent only when normal glutathione homeostasis is compromised, making it a valuable marker of impaired cellular antioxidant capacity and metabolic stress

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There is a wealth of data identifying DPP-4 as a receptor or ligand for a variety of different molecules which, either alone or in combination with its enzymatic activity, allow it affect physiological processes such as the interaction between cells and the extracellular matrix, cell migration, and proliferation

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