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This is because B12 acts on the bone marrow to normalize red blood cell creation, and the life cycle of a red blood cell is 90 days

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Other contraindications and precautions for GLP-1 agonists include a history of severe allergic reactions to the medication or its components, acute or chronic pancreatitis, gallbladder disease or gallstones, and certain forms of diabetic retinopathy

in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )