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The EC50 values (50% maximal effective concentration) were calculated using GraphPad Prism software version 5.0 (La Jolla, CA, USA)

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30 min) significantly inhibits 1 g/mL Doxycycline (HY-N0565)-induced caspase-3/9 activation, reduces reactive oxygen species (ROS) generation and apoptosis, and maintains glutathione levels in thioredoxin TRX2-deficient DT40 cells [1]

4 Differential GLP-1 physiology across obesity, BED, and BN: a mechanistic framework Building on the general pharmacological and physiological mechanisms described in Chapter 2, the following section focuses specifically on differential GLP-1 physiology across obesity, BED, and BN