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When a GLP-1 agonist binds its receptor, it can activate two downstream pathways: cAMP (G-protein) pathway: Mediates the metabolic benefits (insulin secretion, appetite suppression, glucose control) Beta-arrestin pathway: Triggers receptor internalization and desensitization, and may contribute to nausea and vomiting Drugs that preferentially activate the cAMP pathway while minimizing beta-arrestin recruitment -- called "biased agonists" -- may maintain efficacy while reducing GI side effects

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panels are appropriately comprised of experts who are free of conflicts of interest "Guidelines should have a consistent and transparent method of development, be of uniformly high quality, and