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While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

Pernicious anaemia is an autoimmune condition that prevents the binding of vitamin B12 with intrinsic factor and is a common cause of vitamin B12 deficiency

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PMID: 35013352