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In the SURMOUNT-4 trial published in the New England Journal of Medicine, participants who switched from tirzepatide to placebo regained approximately two-thirds of their lost weight over the subsequent 52 weeks, while those continuing treatment maintained their weight loss and achieved additional reductions
In our patients, GLP-1 secretion was lower in both groups and enhanced only in GTE group, but whether the levels of GLP-1 secretion were sufficient could not be determined
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