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Although this study uncovered a possible mechanism by which ferroptosis drives HH, no explanation was given for the clinical observation that patients with type 2 HH present with symptoms earlier, develop more severe tissue damage, and have worse outcomes than patients with type 1 HH (Wang et al., 2017)

298 In addition, IVIGs seem to increase the incidence of several serious adverse events in ARDS patients, such as septic shock, acute kidney injury, and bacterial pneumonia

POP patients exhibit increased levels of inflammatory cytokines (IL-1, TNF, IFN, and others) in the front vaginal wall, which may alter collagen metabolism and contribute to POP

HGPS cells also show persistent markers of high basal DNA damage, such as nuclear ataxia telangiectasia mutated (ATM) foci (Liu Y