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Initial clinical studies evaluating semaglutide in UC have shown promising results, with evidence suggesting significant reductions in disease activity scores, endoscopic inflammation, and histological markers of mucosal injury

However, it seems to have negated the increases in cavernosal pressure that melanocortin agonists potentially induced

It was displayed that BN and related agonists produced a potent contractile response in guinea pig peripheral airways in vitro via a direct effect on bronchial smooth muscle GRP-preferring receptor [52]