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A GRAS substance is distinguished from a food additive on the basis of the common knowledge about the safety of the substance for its intended use

We built an entire regulatory apparatus, the FDA, clinical trials, bioavailability studies, post-market surveillance, specifically because "trust us" from a company with a financial incentive to sell you something is not a substitute for evidence

Some people might run into safety issues when they order GLP-1s online or from compounding pharmacies, where the quality control is more lax

In pediatrics, most available studies do not stratify outcomes by sex, underscoring an important knowledge gap and the urgent need for research that addresses sex-specific responses during childhood and adolescence