[iii] Fosphenytoin is a pharmacokinetic wrecking ball with a broad range of drug-drug interactions (including the induction of P-glycoprotein, CYP2C9, CYP2C19, and CYP3A4)
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Insights into immune dysregulation, cholestatic injury, and bile acid homeostasis have facilitated the development of agents targeting specific pathways, including FXR agonists, PPAR agonists, and immunomodulators
"Without treatment, it is a chronic and relapsing chronic disease that leads to substantial morbidity and mortality," Leddy said at a briefing
