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Storage Store below 25C (air conditioning)

dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies

Maintenance dosing for TB-500 reduces to 2-2.5 mg once weekly or 1-1.5 mg twice weekly, depending on individual response and therapeutic goals