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demonstrated that PPG neurons in the brainstem mediate the reduction of food intake by lorcaserin and that the combination of lorcaserin with GLP-1RA resulted in additive effects on food intake potentially providing a strategy to increase the therapeutic margin of future 5-HT2CR agonists (121)

As highlighted in this review, the relationships between marker variations and biological compartments were often obscured by uneven consideration of fundamental variables such as disease stage, symptoms, treatments, and menstrual cycle phase

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