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However, Cox Regression analysis revealed that in postmenopausal patients with ER66 + /ER36 + tumors, tamoxifen-reduced DFS (HR = 7.705, P = 0.008), while AIs improved DFS and MFS (HR= 0.779 and 0.664, Supplementary information, Table S7)

Assessment of annual cost of substance use disorder in US hospitals

On December 22, 2025, the FDA approved Novo Nordisk's once-daily oral semaglutide (Wegovy pill, 25 mg) for chronic weight management and cardiovascular risk reduction (FDA / Novo Nordisk, 2025)

2019;316:H647-647H663