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B2 cells that participate in the immune system are pro-inflammatory factors that can promote NASH-associated liver fibrosis ( H 2 and T H 17 cells have a pro-fibrogenic impact ( H 17 can stimulate the formation of transforming growth factor- (TGF-), which promotes fibrosis by activating fibroblasts (Meng et al., 2012)

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By addressing these interconnected diseases on a population scale, they achieve far lower healthcare costs and societal burdens than even the combined top cancers