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A phase 2 trial with Retatrutide also noted slight increase in heart rate (around 10bpm) after 24 weeks, but that this increased heart rate subsides over time

The capacity of GLP-1 RAs to decelerate gastric emptying to levels indicative of gastroparesis raises concerns regarding potential intestinal obstruction and perioperative aspiration risk

AI-enabled in silico approaches, in tandem with high-throughput target binding assays (e.g., small-molecule microarrays) and phenotypic screens (perhaps using cAMP+ as a readout), may further uncover some of these incredibly useful molecules

51 SamudraN.Lane-DonovanC.VandevredeL.BoxerA