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Having a wavelength between 650 and 900 nm, NIR radiation has minimal body absorbance, while it could easily penetrate tissue for micrometers to centimeters, allowing photothermal drug release (Xiao et al., 2012)

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The foundational mechanism papers from the Washington State University lab that described how Dihexa works were retracted in April 2025 following a misconduct finding, with a third paper under an Expression of Concern since 2021