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However, human studies directly linking specific cytokine levels to idiopathic tinnitus have yielded mixed results, with some showing alterations in cytokines like IL-10 and IFN- (Mennink et al., 2024)and others finding correlations between tinnitus intensity and IL-6 or TNF- levels (Tanaka et al., 2024), while yet another study in older adults found no broad cytokine differences except for IL-10 in males (Tanaka et al., 2024)

Specifically, GHK-Cu was found to be least possible to cause skin irritation, while CuCl 2 and Cu(OAc) 2 were found to induce the expression of various skin irritation biomarkers, i.e., IL-1, IL-8, FOSL1, and HSPA1A

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Headaches have been reported, though distinguishing these from coincidental occurrences proves difficult