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Yes retatrutide does cause some muscle loss, but it is not uniquely bad for muscle and it is not selectively targeting lean tissue

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These substances can also exist in their respective phosphorylated forms and can be converted, primarily in the liver, to PLP, an active cofactor essential for a number of enzyme-catalyzed reactions

Unlike most peptides for anti-aging that work on surface-level improvements like collagen synthesis , Epithalon targets the fundamental mechanism of cellular aging - telomere length