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The choice between variants depends on goals: systemic anabolism favors IGF-1 LR3, while targeted local effects or minimizing systemic exposure favors IGF-1 DES

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Amino Acids 51:7381 Bellia F, Vecchio G, Rizzarelli E (2014) Carnosinases, their substrates and diseases

Furthermore, as changes occur at varying levels and in different pathways that result in enhancement of neurogenesis, synaptic plasticity, brain structure, and function, CR has also been shown to be beneficial for cognitive protection and improvement of slowing down the progression of cognitive age-related diseases such as Alzheimers disease (Van Cauwenberghe et al., 2016