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Patients with TRD often experience a cyclical treatment pattern characterized by repeated cycles of treatment initiation, dose adjustments, or switching due to tolerability issues or insufficient response

In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids

With the right information and oversight, residents feel ready to act immediately