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As the vitamin is water-soluble and passed through our kidneys in urine, regular replenishment through natural foods can be difficult to maintain

110,111 Diabetic autonomic neuropathy (DAN) DAN is a serious and prevalent complication of diabetes originating from damage to the autonomic nervous system (ANS), which governs involuntary bodily functions

Simultaneously, hydrogen selenide (H 2 Se) generated from the metabolism of dietary selenium species is converted into selenophosphate (H 2 SePO 3 ) by the enzyme selenophosphate synthetase 2 (SEPHS2) which is then used as a substrate by the enzyme O-phosphoseryl-tRNA [Ser]Sec selenium transferase to incorporate selenium into phosphoseryl-tRNA [Ser]Sec to form Sec-tRNA [ser]sec

We also outline current studies that support the involvement of the gut microbiota and mesenchymal cells in the development and progression of UC, with implications for therapeutic development