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Cell aggregate models or spheroid models consist of endothelial cells, astrocytes, and pericytes, which are able to self-organize into spherical structures with astrocyte core, surrounded by pericytes and covered with endothelial cells (Urich et al., 2013)

J Rhuematol 31:645648 Hoque M, Akram T, Saha SN (2023) A review on Methotrexate used in rheumatoid arthritis

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