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(1996) was born with a smaller placenta while igf-1 null mice have placentae of normal size (Liu et al., 1993

At the clinical strategy level, the establishment of quantifiable metabolic readouts, such as the Kyn/Trp ratio, the expression of key metabolic enzymes or transporters, and the proportions of signaling metabolites, combined with stratified interventions based on disease stage and tissue involvement, may help further promote tissue repair and restoration of immune homeostasis while suppressing inflammatory responses, thereby enabling treatment strategies for autoimmune diseases with greater long-term benefit (139)

CoA-LOT: BN20251112/CA

Of note, in agreement with their mechanisms of action, cell treatments with 354 and VX-497 caused opposite effects in steady state levels of IMPDH2: whereas 354 decreased or totally depleted IMPDH2, VX-497 caused a dose-dependent increase of IMPDH2 levels, by a feedback response of the purine synthesis pathway 49,50,51 (Fig