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Trimethylamine N-oxide aggravates liver steatosis through modulation of bile acid metabolism and inhibition of farnesoid x receptor signaling in nonalcoholic fatty liver disease

Clinical and preclinical studies suggest that lactate-enriched solutions confer notable benefits in traumatic brain injury and myocardial ischemia, including reductions in cognitive deficits, improvements in cerebral blood flow and attenuation of reperfusion injuries through mechanisms such as anti-inflammatory effects and provision of alternative energy substrates (156,162)

Studies have demonstrated decreased GPX activity and expression in the erythrocytes/plasma of COPD patients [117,118]

Serum levels of trimethylamine-N-oxide in patients with ischemic stroke